Pravigard Pac and Serzone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using pravastatin together with nefazodone may cause a dangerous side effect on your muscles. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. You should also watch for muscle symptoms and call the doctor if you have muscle pain, tenderness, or weakness, especially if you also have dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: An isolated case report suggests a possible interaction between nefazodone and pravastatin resulting in presumed musculoskeletal toxicity manifested as asymptomatic elevations in creatine kinase level. The mechanism of interaction is unknown, as nefazodone has not been shown to significantly affect pravastatin metabolism or plasma levels. The patient was a 74-year-old man treated with aspirin, atenolol, citalopram, and pravastatin. Citalopram was replaced with nefazodone 50 mg twice daily, and 36 hours later, the patient's creatine kinase level was 877 U/L (baseline level not reported). Lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase were slightly elevated (less than 3 times the upper limit of normal). Following withdrawal of nefazodone, creatine kinase levels declined but remained elevated, so pravastatin was also withdrawn 14 days later. The patient subsequently tolerated pravastatin with venlafaxine 75 mg twice daily without problems.

MANAGEMENT: All patients treated with HMG-CoA reductase inhibitors should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.

Pravigard Pac

Generic Name: aspirin / pravastatin

Brand name: Pravigard Pac

Synonyms: Pravigard PAC

What is Pravigard Pac?

Serzone

Generic Name: nefazodone

Brand name: Serzone

Synonyms: n.a.

What is Serzone?