Premphase Prempro and Rosuvastatin
Determining the interaction of Premphase Prempro and Rosuvastatin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with rosuvastatin may increase the plasma concentrations of certain oral contraceptive hormones. The mechanism of interaction has not been established. According to the manufacturer, concomitant use of rosuvastatin and an oral contraceptive resulted in an increase in ethinyl estradiol and norgestrel area under the plasma concentration-time curve (AUC) of 26% and 34%, respectively. The clinical significance of these alterations is unknown but should be considered when selecting oral contraceptive doses.
- "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc, Mississauga, ON.
Generic Name: conjugated estrogens / medroxyprogesterone
Brand name: Premphase, Prempro
Synonyms: Conjugated estrogens and medroxyprogesterone, Estrogens (Conjugated/Equine) and Medroxyprogesterone
Generic Name: rosuvastatin
Brand name: Crestor, Ezallor Sprinkle
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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