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Premphase Prempro and Tamoxifen

Determining the interaction of Premphase Prempro and Tamoxifen and the possibility of their joint administration.

Check result:

Premphase Prempro <> Tamoxifen

Relevance: 03.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that concomitant administration of medroxyprogesterone may reduce N-demethylation of tamoxifen, but that overall metabolism remains unchanged. The mechanism and the clinical significance of this interaction are unknown.

References

Reid AD, Horobin JM, Newman EL, Preece PE "Tamoxifen metabolism is altered by simultaneous administration of medroxyprogesterone acetate in breast cancer patients." Breast Cancer Res Treat 22 (1992): 153-6

Premphase Prempro

Generic Name: conjugated estrogens / medroxyprogesterone

Brand name: Premphase, Prempro

Synonyms: Conjugated estrogens and medroxyprogesterone, Estrogens (Conjugated/Equine) and Medroxyprogesterone

What is Premphase Prempro?

Tamoxifen

Generic Name: tamoxifen

Brand name: Soltamox, Nolvadex

Synonyms: n.a.

What is Tamoxifen?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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