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Procarbazine Hydrochloride and Wine

Determining the interaction of Procarbazine Hydrochloride and Wine and the possibility of their joint administration.

Check result:

Procarbazine Hydrochloride <> Wine

Relevance: 26.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using procarbazine and ethanol drugs can cause flushing, nausea, headache, or blood pressure changes. Do not consume alcoholic beverages while taking procarbazine. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

GENERALLY AVOID: The combined use of procarbazine and alcohol may result in a disulfiram-like reaction (flushing, nausea, headache, hypotension). Increased sedation may also occur. The mechanism may be due to inhibition of aldehyde dehydrogenase by procarbazine.

MANAGEMENT: The clinician should counsel patients receiving procarbazine to avoid the consumption of alcohol.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Matulane (procarbazine)." Roche Laboratories, Nutley, NJ.

Procarbazine Hydrochloride

Generic Name: procarbazine

Brand name: Matulane

Synonyms: Procarbazine

What is Procarbazine Hydrochloride?

Wine

Generic Name: ethanol

Brand name: Ablysinol

Synonyms: n.a.

What is Wine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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