Sarafem Tablets and Valproic acid
Determining the interaction of Sarafem Tablets and Valproic acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Individual case reports suggest that fluoxetine may increase valproate levels, perhaps by inhibiting the hepatic metabolism of valproate. Another study of two patients suggests that valproate may enhance the therapeutic effects of fluoxetine. The mechanism is unknown. Patients should be monitored for altered pharmacologic effects and increased valproic acid levels if these drugs are administered concomitantly.
- Corrigan FM "Sodium valproate augmentation of fluoxetine or fluvoxamine effects." Biol Psychiatry 31 (1992): 1178-9
- Sovner R, Davis JM "A potential drug interaction between fluoxetine and valproic acid." J Clin Psychopharmacol 11 (1991): 389
Generic Name: fluoxetine
Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra
Synonyms: FLUoxetine, Fluoxetine
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic Acid and Derivatives
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sarafem Tablets-Valproic Acid and Derivatives
- Sarafem Tablets-Valproic Acid Capsules
- Sarafem Tablets-Valproic Acid Liquid
- Sarafem Tablets-Valproic Acid Oral Solution
- Sarafem Tablets-Valproic Acid Syrup
- Sarafem Tablets-Valrubicin
- Valproic acid-Sarecycline
- Valproic acid-Sarecycline Hydrochloride
- Valproic acid-Sargramostim
- Valproic acid-Sargramostim Intravenous
- Valproic acid-Sargramostim Powder for Injection
- Valproic acid-Sargramostim Solution for Injection