Sprycel and Venetoclax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Dasatinib may increase the blood levels of venetoclax in some patients. This may increase your risk of developing tumor lysis syndrome, a serious condition that is caused by the rapid breakdown of cancer cells and that can lead to kidney failure and even death. In addition, you may be more likely to experience other side effects such as nausea; vomiting; diarrhea; fatigue; and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of venetoclax, which is a substrate of both the isoenzyme and efflux transporter. In 11 previously treated non-Hodgkin's lymphoma patients, venetoclax peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.3- and 6.4-fold, respectively, when coadministered with 400 mg once daily for 7 days of ketoconazole, a potent CYP450 3A4 inhibitor that also inhibits P-gp and breast cancer resistance protein (BCRP). The interaction has not been studied with other, less potent inhibitors. Increased venetoclax exposure may potentiate the risk of tumor lysis syndrome, particularly at initiation of therapy and during the dosage ramp-up phase, as well as other adverse effects such as diarrhea, nausea, vomiting, neutropenia, anemia, and thrombocytopenia.

MANAGEMENT: Caution is advised when venetoclax is used with inhibitors of CYP450 3A4. Close clinical and laboratory monitoring for the development of tumor lysis syndrome and myelosuppression is recommended following the addition of a CYP450 3A4, and the venetoclax dosage adjusted if necessary. The dosage may be readjusted 2 to 3 days after discontinuation of the inhibitor.

Sprycel

Generic Name: dasatinib

Brand name: Sprycel

Synonyms: n.a.

What is Sprycel?

Venetoclax

Generic Name: venetoclax

Brand name: Venclexta, Venclexta Starting Pack

Synonyms: n.a.

What is Venetoclax?