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Tagamet and Versacloz

Determining the interaction of Tagamet and Versacloz and the possibility of their joint administration.

Check result:

Tagamet <> Versacloz

Relevance: 06.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using cimetidine together with cloZAPine. Using cimetidine together with cloZAPine can increase the blood levels or add to the side effects of cloZAPine. This can cause shallow breathing, shortness of breath, weak pulse, muscle weakness, headache, excessive drowsiness, and slurred speech. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Cimetidine may significantly increase serum clozapine concentrations and risk of toxicity. The proposed mechanism involves inhibition of the CYP450 1A2 and/or 2C19 hepatic metabolism of clozapine.

MANAGEMENT: Ranitidine, nizatidine and famotidine are not expected to alter clozapine levels and should be considered as alternatives. If cimetidine and clozapine must be combined, close observation for clinical and laboratory evidence of altered clozapine effect is recommended. Patients should be advised to notify their physician if they experience excess drowsiness, sedation, dizziness, syncope, headache, tremor, seizures, nausea, salivation, shortness of breath, or tachycardia.

References

"Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.
Szymanski S, Lieberman JA, Picou D, Masiar S, Cooper T "A case report of cimetidine-induced clozapine toxicity." J Clin Psychiatry 52 (1991): 21-2

Tagamet

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet?

Versacloz

Generic Name: clozapine

Brand name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: n.a.

What is Versacloz?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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