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Tasigna and Tums

Determining the interaction of Tasigna and Tums and the possibility of their joint administration.

Check result:

Tasigna <> Tums

Relevance: 26.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the nilotinib and calcium carbonate doses too close together may interfere with the absorption of nilotinib and reduce its effectiveness. To prevent or minimize the interaction, nilotinib and calcium carbonate dosing should be separated by at least two hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Antacids significantly decrease the oral bioavailability of nilotinib. The mechanism is decreased solubility of nilotinib due to antacid-induced gastric pH increases. Nilotinib's solubility is pH-dependent and it is insoluble at a pH of 4.5 or higher.

MANAGEMENT: Patients treated with nilotinib should not take antacids or other agents with acid-neutralizing effects for at least 2 hours before or 2 hours after a nilotinib dose.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Tasigna

Generic Name: nilotinib

Brand name: Tasigna

Synonyms: n.a.

What is Tasigna?

Tums

Generic Name: calcium carbonate

Brand name: Tums Smoothies, Tums, Cal-Mint, Calci-Chew, Oysco 500, Calci Mix, Os-Cal 500, Oyst Cal 500, Oyster Shell Calcium 500, Nephro Calci, Amitone, Dicarbosil, Equilet, Chooz, Tums E-X, Alkets, Titralac, Oyster Cal 500, Calcitab, Oyster Shell, Oyster Calcium, Super Calcium, Calcium Concentrate, Caltro, Oyster, Oyster Cal, Cal Oys, Alkums, Cal-Gest, Tums 500, Tums Ultra, Alka-Mints, Calcarb, Caltrate, Rolaids Sodium Free, Amilac, Calcium Oyster, Oyst Cal, Calcium Liquid Softgel, Mylanta Child, Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Ultra Mylanta Calci Tabs, Extra Strength Mylanta Calci Tabs, Os-Cal, Surpass, Surpass Extra Strength, Icar Prenatal Chewable Calcium, Tums Extra Strength, Maalox Quick Dissolve Extra Strength, Calcium Oyster Shell, Maalox Antacid Barrier, Rolaids Soft Chew, Pepto Children's, Maalox Regular Strength, Maalox Children's, Tums Kids, Tums QuikPak, Calci-Mix, Alcalak, Tums Chewy Bites, Tums Chewy Delights, Tums Sugar-Free, Calci Mix, OsCal 500

Synonyms: n.a.

What is Tums?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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