Topotecan Injection, Concentrate and Velpatasvir and Sofosbuvir Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Velpatasvir may increase the blood levels of topotecan. This may increase side effects such as nausea, vomiting, diarrhea, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You should seek medical attention if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with velpatasvir may increase the plasma concentrations of topotecan. Although not studied, a clinically significant pharmacokinetic interaction may be anticipated because topotecan is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), and velpatasvir inhibits both of these drug transporters according to the manufacturer.

MANAGEMENT: Concomitant use of topotecan with sofosbuvir-velpatasvir is not recommended.

Topotecan Injection, Concentrate

Generic Name: topotecan

Brand name: Hycamtin

Synonyms: Topotecan (oral/injection), Topotecan

What is Topotecan Injection, Concentrate?

Velpatasvir and Sofosbuvir Tablets

Generic Name: sofosbuvir / velpatasvir

Brand name: Epclusa

Synonyms: Sofosbuvir and velpatasvir, Sofosbuvir and Velpatasvir

What is Velpatasvir and Sofosbuvir Tablets?