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Abilify and EpiPen

Determining the interaction of Abilify and EpiPen and the possibility of their joint administration.

Check result:
Abilify <> EpiPen
Relevance: 17.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

EPINEPHrine may be ineffective for the treatment of excessively low blood pressure, shock, or collapse if you are receiving ARIPiprazole. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Phenothiazines and other neuroleptics may inhibit or reverse the pressor effect of adrenaline (epinephrine), dopamine, and similar vasoconstrictors. Many of these agents, including the atypical antipsychotics, exhibit alpha-1 adrenergic blocking activity and produce hypotension as an adverse effect. Use of adrenaline or dopamine for drug-induced hypotension and circulatory collapse in patients receiving neuroleptic therapy may cause a paradoxical further lowering of blood pressure, since beta stimulation may worsen hypotension in the setting of alpha blockade.

MANAGEMENT: Adrenaline, dopamine, and similar vasoconstrictors should not be used to treat drug-induced hypotension and circulatory collapse in patients taking phenothiazines or other neuroleptic agents. Alternative vasopressor agents such as metaraminol, noradrenaline (norepinephrine), or phenylephrine should be considered, and vital signs closely monitored.

References
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  • "Product Information. Loxitane C Oral Concentrate (loxapine)" Watson Laboratories Inc, Corona, CA.
  • "Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
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  • "Product Information. Abilify (aripiprazole)." Bristol-Myers Squibb, Princeton, NJ.
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  • "Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
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  • "Product Information. Navane (thiothixene)." Roerig Division, New York, NY.
  • "Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • "Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.
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  • "Product Information. Moban (molindone)." Gate Pharmaceuticals, Sellersville, PA.
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Abilify

Generic Name: aripiprazole

Brand name: Abilify, Abilify Discmelt, Abilify Maintena, Aristada, Abilify MyCite, Aristada Initio

Synonyms: n.a.

What is Abilify?
EpiPen

Generic Name: epinephrine

Brand name: Adrenaclick, Adrenalin, Auvi-Q, EpiPen, Twinject, EPIsnap, Epinephrinesnap-EMS, EpiPen 2-Pak, EpiPen JR 2-Pak, Symjepi, Auvi-Q Auto-injector, Primatene Mist Inhaler, Primatene Mist

Synonyms: n.a.

What is EpiPen?
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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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