Abilify Discmelt and Aminoglutethimide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Aminoglutethimide may reduce the blood levels of ARIPiprazole, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the product labeling, administration of aripiprazole (30 mg once a day) with the potent CYP450 3A4 inducer carbamazepine (200 mg twice a day) resulted in approximately 70% decreases in peak plasma concentration (Cmax) and systemic exposure (AUC) for both aripiprazole and its active metabolite, dehydro-aripiprazole.

MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the aripiprazole dosage adjusted as necessary. The manufacturer recommends doubling the aripiprazole dosage when a potent CYP450 3A4 inducer is added to therapy, and additional dosage adjustments made based on clinical evaluation. Potent inducers include carbamazepine, enzalutamide, mitotane, phenobarbital, phenytoin, rifamycins, and St. John's wort. Other known CYP450 inducers include aminoglutethimide, barbiturates, bexarotene, bosentan, dabrafenib, dexamethasone, efavirenz, etravirine, nafcillin, nevirapine, somatrem, somatropin, and various other anticonvulsants, although the extent to which they interact with aripiprazole is unknown. The aripiprazole dosage should be reduced following discontinuation of the CYP450 3A4 inducer.

Abilify Discmelt

Generic Name: aripiprazole

Brand name: Abilify, Abilify Discmelt, Abilify Maintena, Aristada, Abilify MyCite, Aristada Initio

Synonyms: n.a.

What is Abilify Discmelt?

Aminoglutethimide

Generic Name: aminoglutethimide

Brand name:

Synonyms: Aminoglutethimide (Oral)

What is Aminoglutethimide?