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Adhansia XR and Celexa

Determining the interaction of Adhansia XR and Celexa and the possibility of their joint administration.

Check result:

Adhansia XR <> Celexa

Relevance: 04.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Methylphenidate may increase the blood levels and effects of citalopram. You may be more likely to experience side effects, including a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Contact your doctor if you experience increased side effects or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with methylphenidate may increase the plasma concentrations and effects of selective serotonin reuptake inhibitors (SSRIs). Human pharmacologic studies have shown that methylphenidate may inhibit the metabolism of some antidepressants including SSRIs. There have been isolated reports of adverse reactions such as hallucinations, confusion, seizures, and serotonin syndrome during concomitant use of methylphenidate with an SSRI, which resolved following discontinuation of one or both drugs. Nevertheless, the combination has been used therapeutically to improve clinical response in the treatment of attention-deficit hyperactivity disorder and to augment the effects of SSRIs in the treatment of depression.

MANAGEMENT: Pharmacologic response to SSRIs should be monitored more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the dosage of one or both drugs adjusted as necessary.

References

Stoll AL, Pillay SS, Diamond L, Workum SB, Cole JO "Methylphenidate augmentation of serotonin selective reuptake inhibitors: a case series." J Clin Psychiatry 57 (1996): 72-6
Findling RL "Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series." J Child Adolesc Psychopharmacol 6 (1996): 165-75
Lavretsky H, Park S, Siddarth P, Kumar A, Reynolds CF 3rd "Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial." Am J Geriatr Psychiatry 14 (2006): 181-5
Lavretsky H, Kumar A "Methylphenidate augmentation of citalopram in elderly depressed patients." Am J Geriatr Psychiatry 9 (2001): 298-303
"Product Information. Focalin (dexmethylphenidate)." Mikart Inc, Atlanta, GA.
Gammon GD, Brown TE "Fluoxetine and methylphenidate in combination for treatment of attention deficit disorder and comorbid depressive disorder." J Child Adolesc Psychopharmacol 3 (1993): 1-10
"Product Information. Concerta (methylphenidate)." Alza, Palo Alto, CA.
Ishii M, Tatsuzawa Y, Yoshino A, Nomura S "Serotonin syndrome induced by augmentation of SSRI with methylphenidate." Psychiatry Clin Neurosci 62 (2008): 246

Adhansia XR

Generic Name: methylphenidate

Brand name: Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA, Metadate CD, Ritalin SR, Daytrana, Methylin ER

Synonyms: n.a.

What is Adhansia XR?

Celexa

Generic Name: citalopram

Brand name: Celexa

Synonyms: n.a.

What is Celexa?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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