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Adoxa CK and Tegretol XR

Determining the interaction of Adoxa CK and Tegretol XR and the possibility of their joint administration.

Check result:

Adoxa CK <> Tegretol XR

Relevance: 01.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking doxycycline, tell your doctor if you also use carBAMazepine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may decrease the levels of doxycycline in your body. The effectiveness of doxycycline may also be decreased. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Carbamazepine may significantly decrease serum levels and the half-life of doxycycline. The mechanism may be related to induction of doxycycline metabolism. Antimicrobial effectiveness may be decreased and therapeutic failure may occur.

MANAGEMENT: If these drugs must be used together, close monitoring of the patient's clinical response is recommended. An increase in doxycycline dosage may be necessary, or it may be necessary to use an alternative antimicrobial therapy with a renally excreted tetracycline (demeclocycline, oxytetracycline, or tetracycline) or an antimicrobial agent of a different class.

References

Penttila O, Neuvonen PJ, Aho K, Lehtovaara R "Interaction between doxycycline and some antiepileptic drugs." Br Med J 2 (1974): 470-2
Neuvonen PJ, Penttila O, Lehtovaara R, Aho K "Effect of antiepileptic drugs on the elimination of various tetracycline derivatives." Eur J Clin Pharmacol 9 (1975): 147-54

Adoxa CK

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: Adoxa CK (Oral)

What is Adoxa CK?

Tegretol XR

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol XR?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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