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Buprenorphine, Buprenorphine Hydrochloride and Zoladex (Goserelin Implant 10.8 mg)

Determining the interaction of Buprenorphine, Buprenorphine Hydrochloride and Zoladex (Goserelin Implant 10.8 mg) and the possibility of their joint administration.

Check result:
Buprenorphine, Buprenorphine Hydrochloride <> Zoladex (Goserelin Implant 10.8 mg)
Relevance: 25.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using goserelin together with buprenorphine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Long-term androgen deprivation therapy can prolong the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In a single, active-controlled, clinical study comparing abarelix to LHRH (luteinizing hormone releasing hormone) agonist plus nonsteroidal antiandrogen therapy, both therapies were found to prolong the mean Fridericia-corrected QT interval (QTcF) by more than 10 msec from baseline. In approximately 20% of patients in both groups, there were either changes from baseline QTc of greater than 30 msec or end-of-treatment QTc values exceeding 450 msec. Similar results were observed in two other Phase 3 studies with abarelix and the active-control treatments. In a randomized, active-controlled trial comparing degarelix to leuprolide, three patients (

References
  • "Product Information. Vantas (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
  • "Product Information. Zoladex (goserelin)." Zeneca Pharmaceuticals, Wilmington, DE.
  • "Product Information. Eligard (leuprolide)." Sanofi Winthrop Pharmaceuticals, New York, NY.
  • "Product Information. Plenaxis (abarelix)." Praecis Pharmaceuticals Inc, Waltham, MA.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. Trelstar (triptorelin)" Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Firmagon (degarelix)." Ferring Pharmaceuticals Inc, Tarrytown, NY.
  • "Product Information. Lupron (leuprolide)." TAP Pharmaceuticals Inc, Deerfield, IL.
Buprenorphine, Buprenorphine Hydrochloride

Generic Name: buprenorphine

Brand name: Belbuca, Buprenex, Butrans, Probuphine, Sublocade, Subutex

Synonyms: Buprenorphine, Buprenorphine (implant)

Zoladex (Goserelin Implant 10.8 mg)

Generic Name: goserelin

Brand name: Zoladex

Synonyms: Zoladex

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.