Carnexiv and Zontivity

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may reduce the blood levels of vorapaxar, which may make the medication less effective in preventing blood clots. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with rifampin 600 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 35% and 50%, respectively.

MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy.

Carnexiv

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: Carnexiv (Intravenous)

What is Carnexiv?

Zontivity

Generic Name: vorapaxar

Brand name: Zontivity

Synonyms: n.a.

What is Zontivity?