Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate and Zileuton Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Efavirenz may reduce the blood levels and effects of zileuton. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with efavirenz may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is accelerated clearance due to induction of CYP450 3A4 activity by efavirenz.

MANAGEMENT: Caution is advised if efavirenz must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever efavirenz is added to or withdrawn from therapy.

Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate

Generic Name: efavirenz / emtricitabine / tenofovir

Brand name: Atripla

Synonyms: Efavirenz, emtricitabine, and tenofovir

What is Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate?

Zileuton Tablets

Generic Name: zileuton

Brand name: Zyflo, Zyflo CR

Synonyms: Zileuton

What is Zileuton Tablets?