Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate and Zinc sulfate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.ADJUST DOSING INTERVAL: Coadministration with supplements containing polyvalent cations such as zinc may decrease the plasma concentrations of integrase strand transfer inhibitors (INSTIs) such as elvitegravir and raltegravir. The mechanism involves chelation of the INSTI by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The clinical relevance is unknown. MANAGEMENT: If concomitant use is required, monitor for virologic efficacy and administer the INSTI such as elvitegravir or raltegravir at least 2 hours before or 6 hours after supplements containing polyvalent cations such as zinc. References US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Available from: URL: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/287/insti-drug-interactions." ([2019, Nov 6]):

ADJUST DOSING INTERVAL: Coadministration with supplements containing polyvalent cations such as zinc may decrease the plasma concentrations of integrase strand transfer inhibitors (INSTIs) such as elvitegravir and raltegravir. The mechanism involves chelation of the INSTI by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The clinical relevance is unknown.

MANAGEMENT: If concomitant use is required, monitor for virologic efficacy and administer the INSTI such as elvitegravir or raltegravir at least 2 hours before or 6 hours after supplements containing polyvalent cations such as zinc.

Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate

Generic Name: cobicistat / elvitegravir / emtricitabine / tenofovir

Brand name: Genvoya, Stribild

Synonyms: Cobicistat, elvitegravir, emtricitabine, and tenofovir

What is Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate?

Zinc sulfate

Generic Name: zinc sulfate

Brand name: Orazinc 110, Orazinc 220, Zinc, Zinc-220, Zinca-pak, Mar-Zinc, Verazinc, Zincate, Zinc CR, Micro-Zn, Zinc 50 mg Pink

Synonyms: Zinc Sulfate

What is Zinc sulfate?