Extavia and Hydrocodone and Acetaminophen Oral Solution
Determining the interaction of Extavia and Hydrocodone and Acetaminophen Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Interferon beta-1b may cause liver problems, and using it with other medications that can also affect the liver such as acetaminophen may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of beta interferons with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Use of beta interferons has been associated with rare cases of liver injury, including autoimmune hepatitis and severe liver damage leading to hepatic failure, some of which required transplantation. In some cases, these events have occurred in the presence of other drugs that have been associated with hepatic injury. Symptoms of liver dysfunction typically began from 1 to 6 months following the initiation of therapy. Asymptomatic elevation of hepatic transaminases (particularly SGPT) have also been reported but is common with interferon therapy.
MANAGEMENT: The risk of hepatic injury should be considered when beta interferons are used with other potentially hepatotoxic agents (e.g., acetaminophen; alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; cyclosporine (high dosages); disulfiram; endothelin receptor antagonists; other interferons; ketolide and macrolide antibiotics; kinase inhibitors; minocycline; nonsteroidal anti-inflammatory agents; nucleoside reverse transcriptase inhibitors; proteasome inhibitors; retinoids; sulfonamides; tamoxifen; thiazolidinediones; tolvaptan; vincristine; zileuton; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, lomitapide, mipomersen, niacin, and statins; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice). Liver function tests should be monitored at regular intervals and the interferon dosage reduced if SGPT rises above 5 times the upper limit of normal. The dosage may be gradually re-escalated when enzyme levels return to normal. Patients should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, malaise, right upper quadrant pain, dark urine, pale stools, and jaundice. If liver injury is suspected, interferon therapy should be promptly discontinued due to the potential for rapid progression to liver failure.
- "Product Information. Plegridy (peginterferon beta-1a)." Biogen Idec Inc, Cambridge, MA.
- "Product Information. Betaseron (interferon beta-1b)." Berlex, Richmond, CA.
- "Product Information. Rebif (interferon beta-1a)." Serono Laboratories Inc, Norwell, MA.
- "Product Information. Avonex (interferon beta-1a)." Biogen, Cambridge, MA.
Generic Name: interferon beta-1b
Brand name: Betaseron, Extavia
Synonyms: n.a.
Generic Name: acetaminophen / hydrocodone
Brand name: Anexsia, Dolorex Forte, Hycet, Liquicet, Lorcet, Lortab, Maxidone, Norco, Polygesic, Stagesic, Vicodin, Xodol, Zamicet, Zydone, Verdrocet, Lortab 10/325, Lortab 5/325, Lortab 75/325, Lortab Elixir, Zyfrel
Synonyms: Acetaminophen and Hydrocodone, Hydrocodone and Acetaminophen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Extavia-Hydrocodone and Acetaminophen Tablets and Capsules
- Extavia-Hydrocodone and chlorpheniramine
- Extavia-Hydrocodone and Chlorpheniramine Extended-Release Capsules
- Extavia-Hydrocodone and Chlorpheniramine Extended-Release Suspension
- Extavia-Hydrocodone and Chlorpheniramine Oral Solution
- Extavia-Hydrocodone and chlorpheniramine polistirex
- Hydrocodone and Acetaminophen Oral Solution-Extendryl HC
- Hydrocodone and Acetaminophen Oral Solution-Extra-Virt Plus DHA
- Hydrocodone and Acetaminophen Oral Solution-Exubera
- Hydrocodone and Acetaminophen Oral Solution-Eye Allergy Relief
- Hydrocodone and Acetaminophen Oral Solution-Eye Cool
- Hydrocodone and Acetaminophen Oral Solution-Eye Drops