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Lithium Carbonate ER Tablets and Zonalon Topical

Determining the interaction of Lithium Carbonate ER Tablets and Zonalon Topical and the possibility of their joint administration.

Check result:

Lithium Carbonate ER Tablets <> Zonalon Topical

Relevance: 09.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking lithium, tell your doctor if you also use doxepin topical. You may need dose adjustments or special tests in order to safely take both medications together. Elderly patients may be particularly susceptible to this interaction. You should notify your doctor if you have symptoms of memory impairment, confusion, or changes in behavior. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: The concomitant use of lithium and tricyclic antidepressants (TCAs) may potentiate the risk of neurotoxicity and psychotic symptoms, even at therapeutic serum lithium levels. The mechanism is unknown but may be related to synergistic effects on neurotransmission. Mania, myoclonus, tremors, memory difficulties, confusion, serotonin syndrome, and a neuroleptic malignant-like syndrome have been reported in patients treated with TCAs several days after the addition of lithium, in most cases requiring discontinuation of either the TCA or lithium. Elderly patients may be particularly susceptible to this interaction.

MANAGEMENT: Close monitoring for symptoms of neurotoxicity is recommended if TCAs are used with lithium. Dosage adjustment or discontinuation of one or both drugs may be necessary if an interaction is suspected.

References

Kojima H, Terao T, Yoshimura R "Serotonin syndrome during clomipramine and lithium treatment." Am J Psychiatry 150 (1993): 1897
Devanand DP, Sackeim HA, Brown RP "Myoclonus during combined tricyclic antidepressant and lithium treatment." J Clin Psychopharmacol 8 (1988): 446-7
Delisle JD "Rapid switch in a bipolar patient during lithium-tricyclic therapy." Am J Psychiatry 143 (1986): 1326-7
Rosenberg PB, Pearlman CA "NMS-like syndrome with a lithium-doxepin combination." J Clin Psychopharmacol 11 (1991): 75-6
Austin LS, Arana GW, Melvin JA "Toxicity resulting from lithium augmentation of antidepressant treatment in elderly patients." J Clin Psychiatry 51 (1990): 344-5

Lithium Carbonate ER Tablets

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Carbonate ER Tablets?

Zonalon Topical

Generic Name: doxepin topical

Brand name: Prudoxin, Zonalon

Synonyms: Zonalon

What is Zonalon Topical?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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