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Minirin and Zilretta injection

Determining the interaction of Minirin and Zilretta injection and the possibility of their joint administration.

Check result:

Minirin <> Zilretta injection

Relevance: 10.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using desmopressin together with triamcinolone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood. Symptoms may include nausea, vomiting, lethargy, weakness, muscle cramps, twitching, confusion, seizures, and even death in severe cases. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration of desmopressin with loop diuretics or systemic or inhaled glucocorticoids may increase the risk of severe hyponatremia. The proposed mechanism involves additive risk of hyponatremia when these drugs are used concurrently.

MANAGEMENT: The concomitant use of desmopressin with loop diuretics or systemic or inhaled glucocorticoids is considered contraindicated. Treatment with desmopressin can be started or resumed 3 days or 5 half-lives after the glucocorticoid is discontinued, whichever is longer.

References

Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Nocdurna (desmopressin)." Ferring Inc, North York, ON.
"Product Information. Noctiva (desmopressin)." Avadel Pharmaceuticals, Chesterfield, MO.

Minirin

Generic Name: desmopressin

Brand name: DDAVP, Nocdurna, DDAVP nasal, DDAVP Rhinal Tube, Noctiva, Stimate

Synonyms: n.a.

What is Minirin?

Zilretta injection

Generic Name: triamcinolone

Brand name: Kenalog-40, Zilretta, Aristocort, Azmacort

Synonyms: Zilretta (injection), Zilretta

What is Zilretta injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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