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Nuzyra oral/injection and Zinc

Determining the interaction of Nuzyra oral/injection and Zinc and the possibility of their joint administration.

Check result:

Nuzyra oral/injection <> Zinc

Relevance: 26.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Omadacycline and zinc sulfate should not be taken orally at the same time. Products that contain zinc may interfere with the absorption of omadacycline and reduce its effectiveness. If possible, it may be best to avoid taking zinc sulfate while your are being treated with omadacycline. Otherwise, you should separate the dosing of omadacycline and zinc sulfate by at least 3 to 4 hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The bioavailability of oral tetracyclines may be significantly decreased during concurrent administration with zinc-containing products. Therapeutic failure may result. The proposed mechanism is chelation of tetracyclines by the zinc cation, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. In seven healthy volunteers, simultaneous oral administration of zinc sulfate 200 mg and tetracycline 500 mg resulted in a 30% to 40% reduction in tetracycline serum concentrations compared to administration of tetracycline alone. In the same study, doxycycline absorption was not significantly affected by zinc coadministration. Other studies have reported reductions of greater than 50% in tetracycline absorption in the presence of zinc salts.

MANAGEMENT: Patients receiving an oral tetracycline in combination with zinc-containing products should be advised to separate the times of administration by at least three to four hours. Doxycycline may be an appropriate alternative, since its absorption may not be significantly affected by zinc coadministration.

References

"Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc., Boston, MA.
Penttila O, Hurme H, Neuvonen PJ "Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man." Eur J Clin Pharmacol 9 (1975): 131-4
Gothoni G, Neuvonen PJ, Mattila M, Hackman R "Iron-tetracycline interaction: effect of time interval between the drugs." Acta Med Scand 191 (1972): 409-11
Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54
"Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.

Nuzyra oral/injection

Generic Name: omadacycline

Brand name: Nuzyra

Synonyms: Nuzyra (oral/injection), Nuzyra

What is Nuzyra oral/injection?

Zinc

Generic Name: zinc sulfate

Brand name: Orazinc 110, Orazinc 220, Zinc, Zinc-220, Zinca-pak, Mar-Zinc, Verazinc, Zincate, Zinc CR, Micro-Zn, Zinc 50 mg Pink

Synonyms: n.a.

What is Zinc?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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