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Perindopril and Amlodipine and Zileuton Tablets

Determining the interaction of Perindopril and Amlodipine and Zileuton Tablets and the possibility of their joint administration.

Check result:
Perindopril and Amlodipine <> Zileuton Tablets
Relevance: 06.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Zileuton is believed to be a weak inhibitor of cytochrome P450 3A4 enzymes, of which calcium channel blockers are a known substrate. Although no studies have been conducted to verify or quantify the interaction, caution is recommended when using this combination until further data is available.

References
  • "Product Information. Zylo Filmtab (zileuton)." Abbott Pharmaceutical, Abbott Park, IL.
Perindopril and Amlodipine

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: Amlodipine and perindopril

Zileuton Tablets

Generic Name: zileuton

Brand name: Zyflo, Zyflo CR

Synonyms: Zileuton

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle