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Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate and Zyvox (Linezolid Tablets)

Determining the interaction of Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate and Zyvox (Linezolid Tablets) and the possibility of their joint administration.

Check result:
Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate <> Zyvox (Linezolid Tablets)
Relevance: 23.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenylephrine together with linezolid can increase your blood pressure. Contact your doctor if you experience increased side effects or if your condition changes. You may need a dose adjustment or need your blood pressure and heart rate checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Linezolid may potentiate the pressor response to sympathomimetic agents. Linezolid is a reversible, nonselective monoamine oxidase inhibitor (MAOI) and, as such, may enhance sympathomimetic effect by increasing norepinephrine storage in adrenergic neurons. The interaction may be more likely to occur with indirect- or mixed-acting sympathomimetics such as pseudoephedrine or ephedrine than with direct-acting agents like epinephrine, norepinephrine, and isoproterenol. In healthy normotensive subjects, coadministration of linezolid (600 mg every 12 hours for 3 days) and two doses of pseudoephedrine (60 mg each) or phenylpropanolamine (25 mg each) given 4 hours apart resulted in a mean maximum increase in systolic blood pressure of 32 mmHg and 38 mmHg, respectively, compared to baseline. The mean maximum systolic blood pressure during coadministration was also significantly increased compared to either agent alone. Heart rate was not affected. Maximum blood pressure levels were seen 2 to 3 hours after the second dose of phenylpropanolamine or pseudoephedrine, and returned to baseline 2 to 3 hours after peak.

MANAGEMENT: Unless blood pressure and clinical status can be closely monitored, linezolid should not be administered in combination with direct- or indirect-acting sympathomimetic agents (e.g., pseudoephedrine, phenylpropanolamine), vasopressive agents (e.g., epinephrine, norepinephrine), or dopaminergic agents (e.g., dopamine, dobutamine). If the combination is used, lower initial dosages of adrenergic agents such as dopamine or epinephrine are recommended, with careful titration to the desired response.

References
  • "Product Information. Zyvox (linezolid)" Pharmacia and Upjohn, Kalamazoo, MI.
  • Hendershot PE, Antal EJ, Welshman IR, Batts DH, Hopkins NK "Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr." J Clin Pharmacol 41 (2001): 563-72
Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate

Generic Name: carbetapentane / phenylephrine / potassium guaiacolsulfonate

Brand name:

Synonyms: n.a.

Zyvox (Linezolid Tablets)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.