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Polyethylene glycol 3350, sodium and potassium salts and Zide

Determining the interaction of Polyethylene glycol 3350, sodium and potassium salts and Zide and the possibility of their joint administration.

Check result:
Polyethylene glycol 3350, sodium and potassium salts <> Zide
Relevance: 27.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are currently receiving treatment with hydroCHLOROthiazide, let your doctor know before you take polyethylene glycol 3350 with electrolytes. Bowel cleansing can cause dehydration and electrolyte abnormalities, and the risk may be increased if you also use hydroCHLOROthiazide or other medications that can affect kidney function. In severe cases, dehydration and electrolyte abnormalities can lead to irregular heart rhythm, seizures, and kidney problems. You may need a dose adjustment or special tests to safely use both medications. You should use polyethylene glycol 3350 with electrolytes exactly as prescribed by your doctor, and drink plenty of clear fluids before, during, and after the cleansing process to keep yourself hydrated. Contact your doctor if you experience signs and symptoms of low electrolyte levels such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with agents that affect renal function or perfusion such as diuretics, ACE inhibitors, angiotensin receptor blockers, and nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk and/or severity of fluid and electrolyte disturbances associated with the use of bowel cleansing preparations. Fluid and electrolyte disturbances can lead to serious adverse events including cardiac arrhythmias, seizures, and renal impairment.

MANAGEMENT: Caution is advised when bowel cleansing preparations are used in patients treated with agents that affect renal function or perfusion, particularly if they are frail or elderly or have preexisting renal impairment. Baseline and postprocedure labs including serum electrolytes, BUN, and creatinine should be considered. Patients should be advised to drink sufficient quantities of clear fluids before, during, and after bowel cleansing. Hospitalization and intravenous fluid hydration may be appropriate for frail or elderly patients who may be unable to drink an adequate volume of fluid.

References
  • "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories, Braintree, MA.
  • "Product Information. Suclear (polyethylene glycol 3350 with electrolytes)." Braintree Laboratories, Braintree, MA.
Polyethylene glycol 3350, sodium and potassium salts

Generic Name: polyethylene glycol 3350 with electrolytes

Brand name: Colyte with Flavor Packs, GaviLyte-C, GoLYTELY, MoviPrep, NuLYTELY Orange, NuLYTELY with Flavor Packs, PEG-3350 with Electolytes, Plenvu, TriLyte with Flavor Packs, NuLYTELY, TriLyte, Suclear

Synonyms: Polyethylene glycol electrolyte solution, Polyethylene Glycol-Electrolyte Solution

Zide

Generic Name: hydrochlorothiazide

Brand name: Aquazide H, HydroDIURIL, Microzide,

Synonyms: HCTZ, Hydrochlorothiazide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.