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TargaDOX and Zimamox

Determining the interaction of TargaDOX and Zimamox and the possibility of their joint administration.

Check result:
TargaDOX <> Zimamox
Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using doxycycline together with amoxicillin. Combining these medications may reduce the effectiveness of amoxicillin. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.

MANAGEMENT: This combination should be avoided if possible.

References
  • "Product Information. Declomycin (demeclocycline)." Lederle Laboratories, Wayne, NJ.
  • "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
  • Olsson RA, Kirby JC, Romansky MJ "Pneumococcal meningitis in the adult." Ann Intern Med 55 (1961): 545-9
  • Jawetz E "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med 123 (1975): 87-91
  • Lepper MH, Dowling HF "Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin." Arch Intern Med 88 (1951): 489-94
  • Gunnison JB, Coleman VR, Jawetz E "Interference of aureomycin and of terramycin with action of penicillin in vitro." Proc Soc Exp Biol Med 75 (1950): 549-52
TargaDOX

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: Targadox

Zimamox

Generic Name: amoxicillin

Brand name: Amoxil, Moxatag, Trimox

Synonyms: Amoxicillin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction