Vedolizumab and Zoster vaccine, live Subcutaneous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

If you are currently being treated or have recently been treated with vedolizumab, you should let your doctor know before receiving zoster vaccine live. Depending on the dose and length of time you have been on vedolizumab, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of vedolizumab therapy. If you have recently been vaccinated with zoster vaccine live, your doctor may choose to postpone treatment with vedolizumab for a couple of weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: The administration of live, attenuated viral or bacterial vaccines during immunosuppressant therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. There are currently no data on the secondary transmission of infection by live vaccines in patients receiving vedolizumab specifically. Immunosuppressed patients may also have increased adverse reactions and decreased or suboptimal immunologic response to vaccines.

MANAGEMENT: In general, live attenuated vaccines should not be used in patients receiving immunosuppressive therapy. Vaccination should be deferred until after such therapy is discontinued for at least 3 months in most cases, and longer following treatment with agents that have a prolonged elimination half-life. In patients who have recently been vaccinated, such therapy should not be initiated for at least 2 weeks. Vedolizumab labeling recommends that patients be brought up-to-date with all immunizations according to current immunization guidelines prior to initiating treatment. Live vaccines may be administered concurrently with vedolizumab only if the benefits outweigh the risks.

Vedolizumab

Generic Name: vedolizumab

Brand name: Entyvio

Synonyms: n.a.

What is Vedolizumab?

Zoster vaccine, live Subcutaneous

Generic Name: zoster vaccine live

Brand name: Zostavax

Synonyms: Zoster vaccine live, Zoster Vaccine (Live/Attenuated)

What is Zoster vaccine, live Subcutaneous?