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Abacavir, dolutegravir, and lamivudine and Chelated Magnesium

Determining the interaction of Abacavir, dolutegravir, and lamivudine and Chelated Magnesium and the possibility of their joint administration.

Check result:
Abacavir, dolutegravir, and lamivudine <> Chelated Magnesium
Relevance: 09.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Dolutegravir and magnesium amino acids chelate should not be taken orally at the same time. Products that contain aluminum, calcium, iron, magnesium and/or other minerals may interfere with the absorption of dolutegravir and reduce its effectiveness in treating HIV infection. You should take dolutegravir at least two hours before or six hours after the magnesium amino acids chelate dose. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Coadministration with medications containing polyvalent cations such as aluminum, calcium, iron, or magnesium may decrease the oral bioavailability of dolutegravir. The mechanism of interaction has not been established. In 16 study subjects, administration of a single 50 mg dose of dolutegravir simultaneously with an antacid (Maalox) decreased dolutegravir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin; 24 hours post-dose) by 72%, 74% and 74%, respectively, compared to administration without the antacid. When the antacid was administered 2 hours after dolutegravir, the Cmax, AUC and Cmin of dolutegravir decreased by just 18%, 26% and 30%, respectively. Administration of single-dose dolutegravir simultaneously with a multivitamin (One-A-Day) decreased the Cmax, AUC and Cmin of dolutegravir by 35%, 33% and 32%, respectively.

MANAGEMENT: Dolutegravir should be administered 2 hours before or 6 hours after medications containing polyvalent cations such as antacids, laxatives, or mineral supplements.

References
  • "Product Information. Tivicay (dolutegravir)." ViiV Healthcare, Research Triangle Park, NC.
Abacavir, dolutegravir, and lamivudine

Generic Name: abacavir / dolutegravir / lamivudine

Brand name: Triumeq

Synonyms: Abacavir, Dolutegravir, and Lamivudine

Chelated Magnesium

Generic Name: magnesium amino acids chelate

Brand name: Chelated Magnesium, MG Plus Protein, Balnetar, Denorex Extra Strength, DHS Tar Shampoo, Elta Tar, Ionil T, MG217 Medicated Tar, Neutrogena T/Gel, Oxipor VHC, Psoriasin, Scytera, Tarsum, Tegrin Medicated, Theraplex T, Coal Tar, Zetar, G-TAR, Zeprime Tar Emulsion, Ionil T Plus, Pentrax, Denorex, Estar, Betatar Gel, Fototar, Doak Tar, Therapeutic, Neutrogena T/Gel Extra Strength, Denorex Medicated Shampoo and Conditioner, Denorex Dry Scalp, MG217 Psoriasis, Doak Tar Oil, Neutrogena T/Derm, Pentrax Gold, T/Gel Conditioner, Tegrin Medicated Soap, Psorigel, Polytar, Doctar, Cutar, Reme-T, Tera Gel, Exorex, Polytar Mild, Psoriderm, Clinitar, Alphosyl, Alphosyl 2 in 1, Carbo-Dome, Coal Tar Strong, T/Gel, Doak Oil Forte, Amcal Anti Itch Bath Solution, Hamilton Formicare Skin Wash, Apha Keri Tar, Neutrogena T-Gel Conditioner, Orion Coal Tar, Linotar, Exorex Penetrating Emulsion Psoriasis Medication, Apha Keri Tar Gel, Linotar Gel 2, Linotar Gel 3, Hamilton Pine Tar with Menthol, Eczema Cream, Pinetarsol Tar, Resolve Itch Cleansing Gel, PC Tar, Anti-Dandruff, Psoriasin Advanced Treatment, Psoriatar

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.