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Abacavir, dolutegravir, and lamivudine and Ribavirin

Determining the interaction of Abacavir, dolutegravir, and lamivudine and Ribavirin and the possibility of their joint administration.

Check result:

Abacavir, dolutegravir, and lamivudine <> Ribavirin

Relevance: 09.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ribavirin together with lamiVUDine may lead to increased side effects. Contact your doctor if you experience nausea, vomiting, abdominal pain/distention, fatigue, unexplained weight loss, shortness of breath, motor weakness, numbness, tingling, and pain in hands and feet. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of oral ribavirin and nucleoside reverse transcriptase inhibitors (NRTIs) may increase the risk of symptomatic hyperlactatemia and lactic acidosis. Ribavirin itself is a nucleoside analogue, and these agents alone and in combination have been associated with the syndrome of lactic acidosis and severe hepatomegaly with steatosis. Other mitochondrial toxicities associated with the use of nucleoside analogues include lipodystrophy, peripheral neuropathy, and pancreatitis.

MANAGEMENT: Coadministration of ribavirin and NRTIs should be undertaken with caution and only if the benefit is anticipated to outweigh the potential risks. Patients should be advised to promptly seek medical attention if they experience symptoms of toxicity such as nausea, vomiting, abdominal pain/distention, fatigue, unexplained weight loss, tachypnea, dyspnea, motor weakness, numbness, tingling, and pain in hands and feet.

References

Guyader D, Poinsignon Y, Cano Y, Saout L "Fatal lactic acidosis in a HIV-positive patient treated with interferon and ribavirin for chronic hepatitis C." J Hepatol 37 (2002): 289-91
"Product Information. Rebetron (interferon-alfa-2b-ribavirin)." Schering Laboratories, Kenilworth, NJ.
Lafeuillade A, Hittinger G, Chadapaud S "Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection." Lancet 357 (2001): 280-1
"Product Information. Copegus (ribavirin)." Roche Laboratories, Nutley, NJ.

Abacavir, dolutegravir, and lamivudine

Generic Name: abacavir / dolutegravir / lamivudine

Brand name: Triumeq

Synonyms: Abacavir, Dolutegravir, and Lamivudine

What is Abacavir, dolutegravir, and lamivudine?

Ribavirin

Generic Name: ribavirin

Brand name: Rebetol, RibaPak, Ribasphere, RibaTab, Virazole, Copegus, RibaPak 600, Moderiba, Moderiba 800 Dose Pack, Moderiba 1200 Dose Pack, Moderiba 1000 Dose Pack, Moderiba 600 Dose Pack

Synonyms: Ribavirin (Oral Inhalation)

What is Ribavirin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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