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Abacavir, dolutegravir, and lamivudine and Tikosyn

Determining the interaction of Abacavir, dolutegravir, and lamivudine and Tikosyn and the possibility of their joint administration.

Check result:

Abacavir, dolutegravir, and lamivudine <> Tikosyn

Relevance: 09.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dofetilide together with dolutegravir is not recommended. Combining these medications may increase the blood levels and effects of dofetilide. This can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. You should seek immediate medical attention if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with dofetilide. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with dolutegravir may increase the plasma concentrations of dofetilide. The proposed mechanism is dolutegravir inhibition of renal organic cation transporter (OCT2), of which dofetilide is a substrate. Dolutegravir has been shown in vivo to inhibit tubular secretion of creatinine by inhibiting OCT2. Clinically, high plasma levels of dofetilide may increase the risk of QT interval prolongation, which has been associated with ventricular arrhythmias including torsade de pointes and sudden death.

MANAGEMENT: Given the risk for serious and/or life-threatening cardiovascular events associated with increased dofetilide plasma levels, concomitant use with dolutegravir is considered contraindicated.

References

"Product Information. Tivicay (dolutegravir)." ViiV Healthcare, Research Triangle Park, NC.
"Product Information. Tikosyn (dofetilide)" Pfizer US Pharmaceuticals, Atlanta, GA.

Abacavir, dolutegravir, and lamivudine

Generic Name: abacavir / dolutegravir / lamivudine

Brand name: Triumeq

Synonyms: Abacavir, Dolutegravir, and Lamivudine

What is Abacavir, dolutegravir, and lamivudine?

Tikosyn

Generic Name: dofetilide

Brand name: Tikosyn

Synonyms: n.a.

What is Tikosyn?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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