Abacavir, dolutegravir, and lamivudine and Viramune (Nevirapine Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using nevirapine together with dolutegravir. Combining these medications may reduce the blood levels of dolutegravir, which may make the medication less effective in treating HIV infection. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition worsens or you develop new infections during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with nevirapine may theoretically decrease the plasma concentrations of dolutegravir. The interaction has not been specifically studied. However, dolutegravir is partially metabolized by CYP450 3A4, and nevirapine is a known inducer of the isoenzyme. Coadministration with other CYP450 3A4 inducers such as efavirenz, etravirine, rifampin, and tipranavir/ritonavir have been found to significantly reduce dolutegravir systemic exposure (AUC) by over 50% and trough plasma concentration (Cmin; 24 hours postdose) by approximately 75% or more.

MANAGEMENT: Coadministration of dolutegravir with nevirapine should be avoided because there are insufficient data to make dosing recommendations.

Abacavir, dolutegravir, and lamivudine

Generic Name: abacavir / dolutegravir / lamivudine

Brand name: Triumeq

Synonyms: Abacavir, Dolutegravir, and Lamivudine

What is Abacavir, dolutegravir, and lamivudine?

Viramune (Nevirapine Tablets)

Generic Name: nevirapine

Brand name: Viramune, Viramune XR

Synonyms: Viramune

What is Viramune (Nevirapine Tablets)?