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Abacavir, Lamivudine and Zidovudine Tablets and Indinavir

Determining the interaction of Abacavir, Lamivudine and Zidovudine Tablets and Indinavir and the possibility of their joint administration.

Check result:
Abacavir, Lamivudine and Zidovudine Tablets <> Indinavir
Relevance: 14.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Indinavir has been shown to increase the area under the plasma concentration-time curves of the reverse transcriptase inhibitors zidovudine and stavudine by up to 36% and 25%, respectively. Concomitant use has inconsistently affected indinavir plasma concentrations, which have increased by up to 13% or have shown no change. The mechanism of the interaction is not clearly understood, but it may be related to the effects of these drugs on hepatic enzymes. Dosage adjustments are unlikely to be necessary, although it may be appropriate to monitor the patient for zidovudine and/or stavudine toxicity.

References
  • "Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
Abacavir, Lamivudine and Zidovudine Tablets

Generic Name: abacavir / lamivudine / zidovudine

Brand name: Trizivir

Synonyms: Abacavir, lamivudine, and zidovudine, Lamivudine, and Zidovudine

Indinavir

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.