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Abacavir, Lamivudine and Zidovudine Tablets and Up and Up Temporary Minor Arthritis Pain Relief

Determining the interaction of Abacavir, Lamivudine and Zidovudine Tablets and Up and Up Temporary Minor Arthritis Pain Relief and the possibility of their joint administration.

Check result:
Abacavir, Lamivudine and Zidovudine Tablets <> Up and Up Temporary Minor Arthritis Pain Relief
Relevance: 14.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Case reports have suggested that the concomitant use of zidovudine and acetaminophen may potentiate the risk of bone marrow suppression and hepatotoxicity; however data have been conflicting. The mechanism is unknown. Until more information is available, patients taking both drugs concurrently should be monitored for the development of hepatotoxicity and bone marrow toxicity.

References
  • Gill PS, Rarick M, Brynes RK, et al "Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 107 (1987): 502-5
  • Sattler FR, Ko R, Antoniskis D, et al "Acetaminophen does not impair clearance of zidovudine." Ann Intern Med 114 (1991): 937-40
  • Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
  • Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4
  • Ameer B "Acetaminophen hepatotoxicity augmented by zidovudine." Am J Med 95 (1993): 342
  • Shriner K, Goetz MB "Severe hepatoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6
Abacavir, Lamivudine and Zidovudine Tablets

Generic Name: abacavir / lamivudine / zidovudine

Brand name: Trizivir

Synonyms: Abacavir, lamivudine, and zidovudine, Lamivudine, and Zidovudine

Up and Up Temporary Minor Arthritis Pain Relief

Generic Name: acetaminophen

Brand name: Acephen, Feverall, Mapap, Actamin, Anacin AF, Apra, Bromo Seltzer, Children's Tylenol, Elixsure Fever/Pain, Medi-Tabs, Q-Pap, Silapap Childrens, Tactinal, Tempra Quicklets, Tycolene, Tylenol, Vitapap, Children's Silapap, Febrol Solution, Triaminic Fever Reducer, Genapap, Tylenol Junior, Children's Tylenol Meltaways, Junior Tylenol Meltaways, Mapap Infants, Tylenol Infants, Ofirmev, Tylenol 8 Hour, Tylenol Arthritis Pain, Tylophen

Synonyms: Arthritis Pain Relief, Topco Arthritis Pain Relief

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.