Abbokinase and Heparin and Dextrose

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using heparin together with urokinase can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Although this combination is used therapeutically and recommended for certain indications (e.g., acute myocardial infarction, pulmonary embolism), fibrinolytic agents may enhance the anticoagulant effect of heparin. Data have shown that the partial thromboplastin time (PTT) may be significantly increased when fibrinogen concentrations fall in response to thrombolytic therapy. Large studies have reported that the risk of major bleeding is significantly higher when these drugs are given together. Hemorrhages have occurred during heparin infusion, one or more days after thrombolytic administration. Cholesterol embolization syndrome has also been reported rarely with thrombolytics and anticoagulants, when used alone or in combination.

MANAGEMENT: Alteplase is contraindicated in patients with acute ischemic stroke who have received heparin within the last 48 hours and have an elevated activated partial thromboplastin time (aPTT). Patients who are to receive a thrombolytic plus heparin for other indications should be carefully selected according to recommended eligibility criteria. The heparin dosage should be adjusted as appropriate to maintain therapeutic aPTT values. Patients should be closely monitored for signs of bleeding, especially at arterial puncture sites. Thrombolytic and/or anticoagulation therapy should be discontinued immediately if serious or uncontrollable bleeding occurs.

Abbokinase

Generic Name: urokinase

Brand name: Kinlytic, Abbokinase, Abbokinase Open-Cath

Synonyms: Abbokinase (Intravenous)

What is Abbokinase?

Heparin and Dextrose

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin Injection, Heparin

What is Heparin and Dextrose?