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Abciximab and LMD

Determining the interaction of Abciximab and LMD and the possibility of their joint administration.

Check result:

Abciximab <> LMD

Relevance: 26.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dextran, low molecular weight and abciximab is not recommended. Using these medications together can cause you to bleed more easily. Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: The risk of bleeding is increased when dextran and abciximab are administered concurrently. In the EPIC trial, 5 of 11 patients who received low molecular weight dextran, abciximab, and oral anticoagulants developed major bleeding and 4 of 11 had minor bleeding events, while there were no bleeding events in 5 patients who received placebo and dextran.

MANAGEMENT: The use of dextran before percutaneous coronary intervention (PCI) or intent to use it during PCI is considered contraindicated by the manufacturer of abciximab.

References

"Product Information. ReoPro (abciximab)." Lilly, Eli and Company, Indianapolis, IN.

Abciximab

Generic Name: abciximab

Brand name: ReoPro

Synonyms: n.a.

What is Abciximab?

LMD

Generic Name: dextran, low molecular weight

Brand name: LMD

Synonyms: n.a.

What is LMD?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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