Abemaciclib and Dipivefrin Hydrochloride

• Generic Name: abemaciclib
• Dosage Forms: n.a.
• Other Brand Names: Verzenio

Abemaciclib is used to treat advanced hormone-related breast cancer. Abemaciclib is used for this condition only if your tumor tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.

Abemaciclib is sometimes given with other cancer medicines.

Abemaciclib may also be used for purposes not listed in this medication guide.

• Generic Name: dipivefrin ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Propine

Reduction of elevated IOP in patients with open-angle glaucoma. Used alone or in conjunction with other IOP-lowering drugs. May be used as initial therapy or for control of IOP in those patients who have not responded adequately to other antiglaucoma agents.

May be preferred as an alternative to topical epinephrine in some patients (e.g., those with cardiovascular disease) because of increased intraocular penetration (lower doses are needed) and resultant decreased adverse systemic effects (e.g., cardiovascular effects) compared with epinephrine.

Does not produce miosis, accommodative spasm, blurred vision, or night blindness. Less likely than epinephrine to cause adenochrome staining of contact lenses.

Has been used to reduce IOP in the treatment of other ocular conditions, including ocular hypertension and pseudoexfoliative, low-tension, and secondary (e.g., post-angle closure, pigmentary, traumatic, herpes zoster) glaucomas.