Abilify MyCite and Tegretol XR

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using carBAMazepine together with ARIPiprazole. Using these medications together may cause ARIPiprazole to be less effective. If you take both medications together, tell your doctor if you have an increase in psychotic symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with carbamazepine may significantly decrease the plasma concentrations of aripiprazole. The mechanism is carbamazepine induction of CYP450 3A4, the isoenzyme that is partially responsible for the metabolic clearance of aripiprazole. According to the manufacturer, carbamazepine (200 mg twice a day) decreased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of both aripiprazole (30 mg once a day) and its active metabolite, dehydro-aripiprazole, by approximately 70%.

MANAGEMENT: Pharmacologic response to aripiprazole should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. The manufacturer recommends that aripiprazole dosage be doubled when carbamazepine is added to therapy, and additional dosage increases be based on clinical evaluation. Aripiprazole dosage should be reduced accordingly if carbamazepine is discontinued.

Abilify MyCite

Generic Name: aripiprazole

Brand name: Abilify MyCite, Abilify, Abilify Discmelt, Abilify Maintena, Aristada, Aristada Initio

Synonyms: Abilify Mycite

What is Abilify MyCite?

Tegretol XR

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol XR?