Abiraterone and Vesanoid

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Abiraterone may increase the blood levels and effects of tretinoin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with abiraterone acetate may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2C8. Abiraterone is a potent inhibitor of CYP450 2C8 in vitro. In a drug interaction study with healthy subjects, administration of the CYP450 2C8 substrate pioglitazone with a single 1000 mg dose of abiraterone acetate resulted in a 46% increase in pioglitazone systemic exposure (AUC).

MANAGEMENT: Caution is advised if abiraterone acetate is prescribed with medications that undergo metabolism by CYP450 2C8, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever abiraterone acetate is added to or withdrawn from therapy.

Abiraterone

Generic Name: abiraterone

Brand name: Yonsa, Zytiga

Synonyms: Abiraterone Acetate

What is Abiraterone?

Vesanoid

Generic Name: tretinoin

Brand name: Vesanoid

Synonyms: n.a.

What is Vesanoid?