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Ablysinol and Antabuse

Determining the interaction of Ablysinol and Antabuse and the possibility of their joint administration.

Check result:

Ablysinol <> Antabuse

Relevance: 13.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

You should not drink alcoholic beverages or use medicines that contain ethanol during treatment with disulfiram. This can cause flushing, nausea and vomiting, blurred vision, shortness of breath, rapid heart beat, and low blood pressure. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

CONTRAINDICATED: Consumption of ethanol during treatment with disulfiram may cause flushing, nausea, blurred vision, dyspnea, tachypnea, tachycardia, and hypotension. Death has been reported. The mechanism is probably related to inhibition of aldehyde dehydrogenase, the enzyme responsible for the oxidation of acetaldehyde to acetyl CoA. Accumulation of acetaldehyde probably results.

MANAGEMENT: Ethanol should be avoided in patients receiving disulfiram.

References

van Ieperen L "Sudden death during disulfiram-ethanol reaction." S Afr Med J 66 (1984): 165
Stoll D, King LE "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA 244 (1980): 2045
Jones RO "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J 60 (1949): 609-12

Ablysinol

Generic Name: ethanol

Brand name: Ablysinol

Synonyms: n.a.

What is Ablysinol?

Antabuse

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Antabuse?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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