Abobotulinumtoxina Intramuscular and Isavuconazonium Sulfate

• Generic Name: abobotulinumtoxinA
• Dosage Forms: n.a.
• Other Brand Names: Dysport

AbobotulinumtoxinA is used to treat the abnormal head position and neck pain that result from cervical dystonia (severe muscle spasms of the neck). Abobotulinumtoxina is also used cosmetically to improve the appearance of deep facial lines or wrinkles between the eyebrows (glabellar lines). It is also used to treat upper and lower limb spasms.

AbobotulinumtoxinA is a botulinum toxin A product. It works on the nervous system to relax the muscles.

Abobotulinumtoxina is available only with your doctor's prescription and will be administered by your doctor.

• Generic Name: isavuconazonium
• Dosage Forms: n.a.
• Other Brand Names: Cresemba

Treatment of invasive aspergillosis; designated an orphan drug by FDA for this indication.

IDSA considers IV voriconazole the drug of choice for primary treatment of invasive aspergillosis; amphotericin B and isavuconazonium recommended as alternatives for primary treatment. For salvage therapy in patients refractory to or intolerant of primary antifungal therapy, IDSA recommends IV amphotericin B, an IV echinocandin (caspofungin, micafungin), oral or IV posaconazole, or itraconazole oral suspension.

Mucormycosis

Treatment of invasive mucormycosis; designated an orphan drug by FDA for this indication.

Esophageal Candidiasis

Treatment of esophageal candidiasis.

Esophageal candidiasis requires treatment with a systemic antifungal (not a topical antifungal).

IDSA recommends oral fluconazole as the preferred drug of choice for treatment of esophageal candidiasis; if oral therapy not tolerated, IV fluconazole or an IV echinocandin (anidulafungin, caspofungin, micafungin) recommended.

For treatment of esophageal candidiasis in HIV-infected adults, CDC, NIH, and IDSA recommend oral or IV fluconazole or itraconazole oral solution. Oral or IV voriconazole, oral isavuconazonium, an IV echinocandin (anidulafungin, caspofungin, micafungin), or IV amphotericin B recommended as alternatives.

Candidemia and Other Invasive Candida Infections

Has been used for treatment of candidemia and other invasive infections caused by Candida; designated an orphan drug by FDA for treatment of invasive candidiasis/candidemia.