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Abstral and Methohexital

Determining the interaction of Abstral and Methohexital and the possibility of their joint administration.

Check result:

Abstral <> Methohexital

Relevance: 22.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Narcotic analgesics may reduce the dosage of methohexital needed to induce anesthesia. Close monitoring of vital signs is necessary so that anesthetic dosages may be adjusted accordingly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Narcotic analgesics may reduce the dosage of barbiturate anesthetics needed to induce anesthesia by as much as 40%. Additionally, apnea is more common with this combination.

MANAGEMENT: Respiratory and cardiovascular status should be closely monitored, and anesthetic dosages titrated accordingly.

References

Stambaugh JE, Wainer IW, Schwartz I "The effect of phenobarbital on the metabolism of meperidine in normal volunteers." J Clin Pharmacol 18 (1978): 482-90
DeLapa RJ "Influence of alphaprodine hydrochloride on intravenous barbiturate induction dosage." J Oral Surg 18 (1960): 163-8
Stambaugh JE, Hemphill DM, Wainer IW, Schwartz I "A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone." Lancet 1 (1977): 398-9
Dundee JW, Halliday NJ, McMurray TJ, Harper KW "Pretreatment with opioids: the effect on thiopentone induction requirements and on the onset of action of midazolam." Anaesthesia 41 (1986): 159-61

Abstral

Generic Name: fentanyl

Brand name: Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze

Synonyms: Abstral Sublingual Tablet

What is Abstral?

Methohexital

Generic Name: methohexital

Brand name: Brevital Sodium

Synonyms: n.a.

What is Methohexital?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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