Abstral and Pazopanib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

PAZOPanib may increase the blood levels and effects of fentaNYL. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of substrates of CYP450 3A4, 2D6, or 2C8 with pazopanib may increase their plasma concentrations. The mechanism is inhibition of CYP450-mediated metabolism by pazopanib. In clinical studies, the concomitant use of pazopanib increased the AUC and Cmax of midazolam by 30%, and increased the AUC and Cmax of paclitaxel by 26% and 31%, respectively.

MANAGEMENT: Due to the potential for adverse effects, the concomitant use of pazopanib with drugs that have narrow therapeutic ranges and that are substrates of CYP450 3A4, 2D6, or 2C8 is not recommended.

Abstral

Generic Name: fentanyl

Brand name: Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze

Synonyms: Abstral Sublingual Tablet

What is Abstral?

Pazopanib

Generic Name: pazopanib

Brand name: Votrient

Synonyms: n.a.

What is Pazopanib?