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Abstral and Technetium tc 99m mebrofenin Intravenous

Determining the interaction of Abstral and Technetium tc 99m mebrofenin Intravenous and the possibility of their joint administration.

Check result:

Abstral <> Technetium tc 99m mebrofenin Intravenous

Relevance: 22.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before you undergo any imaging procedure where mebrofenin may be used, let your doctor know if you are currently receiving fentaNYL. Treatment with medications like fentaNYL may interfere with imaging of the gallbladder by slowing the passage of mebrofenin through the gastrointestinal tract. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Prior administration of opioids may delay transit of Technetium Tc 99m mebrofenin due to opioid-induced contraction of the distal common bile duct, which may result in nonvisualization. In one study, a group of investigators reviewed the records of 198 emergency department patients who underwent nuclear hepatobiliary imaging, after excluding those with evidence for pathologic common bile duct (CBD) obstruction. Delayed CBD visualization occurred in 28.6% of subjects who had received opioids (n=56) and 12.0% of subjects who had not received opioids, while delayed imaging was performed in 77.8% and 53.5%, respectively. The relative risk of delayed CBD visualization was 1.46 for meperidine, 4.18 for morphine, and 2.38 for any opioid. Nonetheless, low-dose intravenous morphine has been used during cholescintigraphy to increase biliary pressure, thereby allowing for visualization of gallbladder when there is failure to visualize 60 minutes or more after Technetium Tc 99m mebrofenin injection. Compared to standard cholescintigraphy, morphine-augmented cholescintigraphy has been shown to reduce imaging time and the number of false-positive results.

MANAGEMENT: Nonvisualization may occur in patients who have been receiving opioids prior to cholescintigraphy.

References

Oates E, Selland DL, Chin CT, Achong DM "Gallbladder nonvisualization with pericholecystic rim sign: morphine-augmentation optimizes diagnosis of acute cholecystitis." J Nucl Med 37 (1996): 267-9
Fink-Bennett D, Balon H, Robbins T, Tsai D "Morphine-augmented cholescintigraphy: its efficacy in detecting acute cholecystitis." J Nucl Med 32 (1991): 1231-3
Flancbaum L, Choban PS, Sinha R, Jonasson O "Morphine cholescintigraphy in the evaluation of hospitalized patients with suspected acute cholecystitis." Ann Surg 220 (1994): 25-31
Chen CC, Holder LE, Maunoury C, Drachenberg CI "Morphine augmentation increases galllbladder visualization in patients pretreated with cholecystokinin." J Nucl Med 38 (1997): 644-7
Kim EE, Pjura G, Lowry P, Nguyen M, Pollack M "Morphine-augmented cholescintigraphy in the diagnosis of acute cholecystitis." AJR Am J Roentgenol 147 (1986): 1177-9
"Product Information. Choletec (mebrofenin)." Bracco Diagnostics Inc, Princeton, NJ.

Abstral

Generic Name: fentanyl

Brand name: Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze

Synonyms: Abstral Sublingual Tablet

What is Abstral?

Technetium tc 99m mebrofenin Intravenous

Generic Name: mebrofenin

Brand name: Choletec

Synonyms: Technetium Tc 99m Mebrofenin, Mebrofenin

What is Technetium tc 99m mebrofenin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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