Abstral Sublingual Tablet and Ranolazine ER Tablets
Determining the interaction of Abstral Sublingual Tablet and Ranolazine ER Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ranolazine may increase the blood levels and effects of fentaNYL. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ranolazine may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 3A4 by ranolazine. The interaction may be significant for sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index.
MANAGEMENT: Caution is advised if ranolazine is used in combination with sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index (e.g., ergot alkaloids, colchicine, fentanyl, macrolide immunosuppressants, midazolam, triazolam, vinca alkaloids). Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever ranolazine is added to or withdrawn from therapy.
- Pierce DA, Reeves-Daniel AM "Ranolazine-tacrolimus interaction." Ann Pharmacother 44 (2010): 1844-9
- "Product Information. Ranexa (ranolazine)." Calmoseptine Inc, Huntington Beach, CA.
Generic Name: fentanyl
Brand name: Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze
Synonyms: Abstral
Generic Name: ranolazine
Brand name: Ranexa
Synonyms: Ranolazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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