ACAM2000 and Fingolimod

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

If you are currently being treated or have recently been treated with fingolimod, you should talk to your doctor before receiving smallpox vaccine. Depending on the dose and length of time you have been on fingolimod, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of fingolimod therapy. If you have recently been vaccinated with smallpox vaccine, your doctor may choose to postpone treatment with fingolimod for a month. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: The administration of live smallpox virus vaccine during fingolimod therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus in the presence of diminished immune competence. Fingolimod causes reversible sequestration of lymphocytes in lymphoid tissues. A dose-dependent reduction in peripheral lymphocyte count to 20% to 30% of baseline values has been observed, which may increase the risk of infections. Cases of generalized vaccinia and progressive vaccinia have been reported in HIV patients who received the smallpox vaccine. Vaccination may also be less effective during and for up to two months after discontinuation of fingolimod therapy.

MANAGEMENT: Routine, nonemergency smallpox vaccination is contraindicated in patients receiving immunosuppressive therapy including fingolimod. Vaccination should be avoided during and for two months after treatment with fingolimod. In patients who have recently been vaccinated, fingolimod therapy should be postponed for one month to allow the full effect of vaccination to occur. Household contacts of immunosuppressed patients should also not be vaccinated. However, there are no absolute contraindications to vaccination if a high-risk exposure has occurred. In an outbreak emergency, smallpox vaccine is recommended for all persons, regardless of medical conditions. The risk for experiencing serious complications from the vaccine should be weighed against the risk of acquiring a potentially fatal smallpox infection.

ACAM2000

Generic Name: smallpox vaccine

Brand name:

Synonyms: n.a.

What is ACAM2000?

Fingolimod

Generic Name: fingolimod

Brand name: Gilenya

Synonyms: n.a.

What is Fingolimod?