AccessPak for HIV PEP Expanded with Viracept and Indinavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using nelfinavir together with indinavir can increase the blood levels or add to the side effects of either medication. Contact your doctor if you experience increased urination or extreme thirst, easy bruising or bleeding, or signs of a new infection, such as fever or chills, cough, or flu symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The combination of nelfinavir and indinavir has been reported to cause an 83% increase in nelfinavir area under the plasma concentration-time curve (AUC) and a 51% increase in the indinavir AUC. The mechanism is likely related to CYP450 3A4 hepatic enzyme inhibition. The safety of their concurrent use has not been established.

MANAGEMENT: Patients should be monitored for adverse effects. Dose adjustments may be required; however, appropriate doses have not been established for this combination.

AccessPak for HIV PEP Expanded with Viracept

Generic Name: emtricitabine / nelfinavir / tenofovir

Brand name: AccessPak for HIV PEP Expanded with Viracept

Synonyms: n.a.

What is AccessPak for HIV PEP Expanded with Viracept?

Indinavir

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Indinavir?