Accolate and Alka-Seltzer Plus Cold Formula
Determining the interaction of Accolate and Alka-Seltzer Plus Cold Formula and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using zafirlukast together with aspirin may increase the effects of zafirlukast. Contact your doctor if you experience worsening asthma symptoms, skin rash, bruising, severe tingling, numbness, pain, muscle weakness, nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Aspirin may increase the plasma concentrations of zafirlukast. Coadministration of zafirlukast (40mg/day) and aspirin (650mg QID) has produced an approximately 45% increase in zafirlukast plasma concentrations. The mechanism and clinical significance are unknown.
MANAGEMENT: Patients receiving this combination should be observed for changes in the efficacy and safety of zafirlukast when aspirin is started, stopped, or changed in dosage. Zafirlukast dosage may need to be adjusted.
- "Product Information. Accolate (zafirlukast)." Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: aspirin / chlorpheniramine / phenylephrine
Brand name: Alka-Seltzer Plus Cold Formula
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Accolate-Alka-Seltzer Plus Cold Liquigel
- Accolate-Alka-Seltzer Plus Flu Liquigels
- Accolate-Alka-Seltzer Plus Flu/Body
- Accolate-Alka-Seltzer Plus Night-Time Cold
- Accolate-Alka-Seltzer Plus-D Sinus/Cold
- Accolate-Alkeran
- Alka-Seltzer Plus Cold Formula-Accretropin
- Alka-Seltzer Plus Cold Formula-Accucaine
- Alka-Seltzer Plus Cold Formula-AccuHist Drops
- Alka-Seltzer Plus Cold Formula-AccuHist PDX Drops
- Alka-Seltzer Plus Cold Formula-AccuHist PDX Syrup
- Alka-Seltzer Plus Cold Formula-Accuneb