Accolate and Theo-24

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using theophylline together with zafirlukast may alter the blood levels of both drugs. Contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration of theophylline with zafirlukast may modestly reduce zafirlukast plasma concentrations. The mechanism is unknown. A single study in 13 asthmatic patients reported a 30% decrease in mean zafirlukast concentration. The clinical significance of this reduction is unclear. In addition, a single case report suggested that zafirlukast may significantly increase theophylline serum concentrations. According to the manufacturer, coadministration of zafirlukast and theophylline in 16 healthy 6- to 11-year-old subjects did not resulted in significant changes to theophylline pharmacokinetics. However, there have been rare postmarketing reports of increased theophylline levels with or without clinical toxicity after zafirlukast was added to the regimen. The mechanism and clinical significance are unknown.

MANAGEMENT: If there is any change in either drug's regimen, the patient should be observed for altered theophylline and zafirlukast effect, and theophylline levels should be monitored closely. Other methylxanthines may interact with zafirlukast in a similar manner.

Accolate

Generic Name: zafirlukast

Brand name: Accolate

Synonyms: n.a.

What is Accolate?

Theo-24

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: n.a.

What is Theo-24?