Accretropin and Imbruvica (Ibrutinib Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Somatropin may reduce the blood levels and effects of ibrutinib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ibrutinib, which is primarily metabolized by the isoenzyme. Preliminary pharmacokinetic data from an ongoing dedicated drug interaction trial and simulations using physiologically based pharmacokinetic models indicate that rifampin, a potent CYP450 3A4 inducer, can decrease ibrutinib peak plasma concentration (Cmax) and systemic exposure (AUC) by more than 10-fold. Pharmacokinetic modeling also suggests that a moderate CYP450 3A4 inducer such as efavirenz may decrease the AUC of ibrutinib up to 3-fold.

MANAGEMENT: The potential for diminished therapeutic effects of ibrutinib should be considered when prescribed in combination with CYP450 3A4 inducers. Patients should be closely monitored, and the dosage of ibrutinib adjusted as necessary in accordance with product labeling.

Accretropin

Generic Name: somatropin

Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit

Synonyms: n.a.

What is Accretropin?

Imbruvica (Ibrutinib Tablets)

Generic Name: ibrutinib

Brand name: Imbruvica

Synonyms: Imbruvica

What is Imbruvica (Ibrutinib Tablets)?