Accretropin and Lapatinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using lapatinib together with somatropin. Combining these medications may reduce the blood levels and effects of lapatinib. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of lapatinib, which is primarily metabolized by the isoenzyme. In healthy subjects, administration of lapatinib in combination with the CYP450 3A4 inducer carbamazepine (100 mg twice daily for 3 days, then 200 mg twice daily for 14 days) resulted in a 72% reduction of lapatinib systemic exposure (AUC) compared to control.

MANAGEMENT: The use of lapatinib in combination with potent CYP450 3A4 inducers such as carbamazepine, dexamethasone, phenobarbital, phenytoin, rifamycins, and St. John's wort should generally be avoided. If concomitant use is unavoidable, the manufacturer recommends titrating the lapatinib dosage gradually from 1250 mg/day up to 4500 mg/day depending on patient tolerability. Based on pharmacokinetic studies, this dosage is predicted to adjust the lapatinib systemic exposure (AUC) to the range observed without inducers. However, clinical data are lacking. The dosage should be reduced to the indicated dosage following discontinuation of the potent CYP450 3A4 inducer. Other known inducers include aminoglutethimide, barbiturates, bexarotene, bosentan, dabrafenib, efavirenz, etravirine, nafcillin, nevirapine, somatrem, somatropin, and various other anticonvulsants, although the extent to which they interact with lapatinib is unknown.

Accretropin

Generic Name: somatropin

Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit

Synonyms: n.a.

What is Accretropin?

Lapatinib

Generic Name: lapatinib

Brand name: Tykerb

Synonyms: n.a.

What is Lapatinib?