About us Contacts Drug interactions: 390 212
Drug search by name

AccuHist Drops and Phenytoin injection

Determining the interaction of AccuHist Drops and Phenytoin injection and the possibility of their joint administration.

Check result:
AccuHist Drops <> Phenytoin injection
Relevance: 03.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chlorpheniramine together with phenytoin can increase the effects of phenytoin. Contact your doctor if you experience drowsiness, visual disturbances, change in mental status, nausea, loss of muscle coordination, or involuntary movements. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Toxic serum concentrations of phenytoin and involuntary movements have been reported during coadministration with chlorpheniramine. Symptoms resolved after chlorpheniramine was discontinued. The mechanism of this interaction is not known.

MANAGEMENT: Clinical monitoring of patient response, tolerance, and serum phenytoin concentrations is recommended. Patients should be advised to notify their physician if they experience symptoms of phenytoin toxicity (drowsiness, visual disturbances, change in mental status, nausea, or ataxia) or involuntary movements.

References
  • Ahmad S, Laidlaw J, Houghton GW, Richens A "Involuntary movements caused by phenytoin intoxication in epileptic patients." J Neurol Neurosurg Psychiatry 38 (1975): 225-31
  • Pugh RN, Geddes AM, Yeoman WB "Interaction of phenytoin with chlorpheniramine." Br J Clin Pharmacol 2 (1975): 173-5
AccuHist Drops

Generic Name: chlorpheniramine / phenylephrine

Brand name: Actifed Cold & Allergy, Allan Tannate Pediatric, Allerest PE, BP Allergy JR, ChlorTan D, Cold & Allergy Relief, Dallergy Drops, Ed A-Hist, Ed ChlorPed D, NoHist LQ, Phenagil, R-Tanna, Sinus & Allergy PE, Sudafed PE Sinus & Allergy, Phenylhistine, Ru-Tuss, Novahistine Elixir, Histatab Plus, Ed A-Hist LA, Rynatan Pediatric, Rynatan, Phenchlor Tannate Pediatric, Relera, Rondec Drops, Rondec, Ceron, Ceron Drops, Chlor-Mes Jr, Dallergy-JR, Rondex, Rondex Drops, Ny-Tannic, Dec-Chlorphen, Dec-Chlorphen Drops, C Phen Drops, C Phen, Tannate Pediatric, Histadec, PediaTan D, Rescon-Jr, CP Dec, Cardec Drops, P-Tann D, Triaminic Cold & Allergy, Rinate Pediatric, Cardec, AlleRx, Sildec-PE Drops, Sildec-PE, Nasohist Pediatric, PD-Hist D Drops, PD-Hist D, CP Dec Drops, Tanahist-D, Ry-Tann, Sonahist, Sinus & Allergy Maximum Strength, NoHist, Trigofen Drops, Lohist, Virdec, Maxichlor PEH, Giltuss Allergy & Sinus, Novahistine, Triaminic Cold/Allergy

Synonyms: n.a.

Phenytoin injection

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction